The 1980–81 season of the Moroccan Throne Cup was the 25th edition of the competition.
Wydad Athletic Club won the cup, beating CODM Meknès 2–1 in the final, played at the Prince Moulay Abdellah Stadium in Rabat. Wydad Athletic Club won the title for the fourth time in their history.
Tournament Last 16 Team 1 Team 2 Result Wydad Athletic Club Chabab Mohammédia 1–0 Maghreb de Fès Raja Club Athletic 1–0 Mouloudia Club d'Oujda CODM Meknès 0–1match replayed after 2–2 draw Renaissance de Berkane Moghreb de Tetouan 0–1match replayed after 0–0 draw Fath Union Sport Renaissance de Settat 0–1 Jeunesse Kénitra Nejm Shabab Bidawi 0–2match replayed after 1–1 draw Difaâ Hassani El Jadidi Olympic Club de Safi 1–2 Ittihad Riadi Fkih Ben Salah Olympique de Khouribga 4–2
Quarter-finals Team 1 Team 2 Result Wydad Athletic Club Renaissance de Settat 2–0 CODM Meknès Moghreb de Tetouan 4–0 Maghreb de Fès Ittihad Riadi Fkih Ben Salah 1–2 Nejm Shabab Bidawi Olympic Club de Safi 2–1
Semi-finals Team 1 Team 2 Result Nejm Shabab Bidawi CODM Meknès 0–1 Wydad Athletic Club Ittihad Riadi Fkih Ben Salah 4–0
Final The final was played between the two winning semi-finalists, Wydad Athletic Club and CODM Meknès, on 16 September 1980 at the Prince Moulay Abdellah Stadium in Rabat.
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