Osawatomie may refer to:
Political positions of Theodore Roosevelt#New Nationalism and judicial review, Speech on August 31, 1910 at Osawatomie, Kansas, when Theodore Roosevelt announced his "New Nationalism"
Osawatomie, Kansas Osawatomie High School Battle of Osawatomie, engagement in Bleeding Kansas struggle Osawatomie Brown, an 1859 play by Kate Edwards about John Brown. John "Osawatomie" Brown, the abolitionist. Osawatomie (periodical)