The 2018 Samarkand Challenger was a professional tennis tournament played on clay courts. It was the 22nd edition of the tournament which was part of the 2018 ATP Challenger Tour. It took place in Samarkand, Uzbekistan between 14 and 19 May 2018.

Singles main-draw entrants Seeds Country Player Rank1 SeedDenis Istomin911Attila Balázs1982Nikola Milojević2003Uladzimir Ignatik2254Lloyd Harris2315Aleksandr Nedovyesov2326Egor Gerasimov2367Yang Tsung-hua2478 1 Rankings are as of May 7, 2018.

Other entrants The following players received wildcards into the singles main draw: Farrukh Dustov Sanjar Fayziev Denis Istomin Jurabek Karimov

The following player received entry into the singles main draw as a special exempt: Sergey Betov

The following players received entry from the qualifying draw: Sriram Balaji Sergey Fomin Manuel Peña López Roman Safiullin

Champions Singles

Luca Vanni def. Mario Vilella Martínez 6–4, 6–4.

Doubles

Sriram Balaji / Vishnu Vardhan def. Mikhail Elgin / Denis Istomin, walkover.

References