Tomassoni is an Italian surname. Notable people with the surname include:
David Tomassoni (1952–2022), American politician Mirko Tomassoni (born 1969), Captain Regent of San Marino Ronn Tomassoni (born 1958), American ice hockey player and coach Thomas Tomassoni (1616–1654), Italian Roman Catholic bishop
See also Tomassoni awards, an Italian physics award