The 1977–78 Macedonian Republic League was the 34th since its establishment. FK Tikvesh won their 2nd championship title.
Participating teams Club City 11 Oktomvri Prilep Balkan Skopje Belasica Strumica Gostivar Gostivar Jugokokta Skopje Karaorman Struga Kozhuf Gevgelija Kumanovo Kumanovo Ohrid Ohrid Osogovo Kochani Pelister Bitola Pobeda Valandovo Skopje Skopje Sloga Skopje Skopje Sloga Vinica Vinica Tikvesh Kavadarci Transkop Bitola Vardar Negotino
Final table
External links SportSport.ba Football Federation of Macedonia