Hylaeus mesillae is a species of bee in the family Colletidae. It is found in Central America and North America.
Subspecies These three subspecies belong to the species Hylaeus mesillae: Hylaeus mesillae cressoni (Cockerell, 1907) Hylaeus mesillae cressonii Cockerell, 1907 Hylaeus mesillae mesillae (Cockerell, 1896)
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