The Isham Henderson House, on Main Cross Rd. in New Castle in Henry County, Kentucky, was built . It was listed on the National Register of Historic Places in 1987. The listing included two contributing buildings (a stone house and a frame dependency) and a contributing structure (a root cellar). With

The house is a six-bay one-story hip roof dry stone house with a rear ell. It has nine-stone voussoirs without keystones. It had Federal/Greek transitional-style woodwork.

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