HOTB can stand for:
Hang on the Box, an all-female punk band from Beijing, China. In the Heart of the Beast Puppet and Mask Theatre, a puppet theater company from Minneapolis, Minnesota Home of the Brave, a phrase from The Star-Spangled Banner and the name of several films Hooked on the Brothers, a phrase from the introduction of the 1989 television show The Super Mario Bros. Super Show!. The Hound of the Baskervilles, a 1902 mystery novel by Arthur Conan Doyle featuring Sherlock Holmes. Houses of the Blooded, a roleplaying game designed by John Wick.