Psaila is a Maltese surname. Notable people with the surname include:
Dun Karm Psaila (1871–1961), priest, writer and poet regarded as the "National Poet of Malta" Gejtu Psaila (1893–1968), footballer Giuseppe Psaila (1891–1960), Art Nouveau architect Jes Psaila (born 1964), guitarist Natalie Psaila, Maltese doctor and abortion-rights activist Pippo Psaila (born 1957), football coach Salvatore Psaila (1798–1871), Maltese sculptor