Leptomydinae is a subfamily of mydas flies in the family Mydidae primarily distributed in the Northern Hemisphere.

Genera Eremomidas Semenov, 1896 Hessemydas Carr & Irwin, 2005 Leptomydas Gerstaecker, 1868 Nemomydas Curran, 1934 Plyomydas Papavero, 1971 Pseudonomoneura Bequaert, 1961

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