Sobrino is a Spanish surname. Notable people with the surname include:
People Enrique Molina Sobrino, founder of Gemex, a Pepsi bottling company in Mexico María Reyes Sobrino (born 1967), Spanish racewalking athlete Francisco Sobrino (1932–2014), Spanish sculptor who lived in Paris Joaquín Sobrino (born 1982), Spanish cyclist Jon Sobrino (born 1938), Jesuit Catholic priest and liberation theologian Juan Sobrino, civil engineer specializing in bridge construction Rubén Sobrino (born 1992), Spanish professional footballer
Other Sobrino de Botín, a restaurant in Madrid operating since 1725