The following lists events that happened during 2006 in the Democratic Republic of São Tomé and Príncipe.
Incumbents President: Fradique de Menezes Prime Minister: Maria do Carmo Silveira (until 21 April), Tomé Vera Cruz (from 21 April)
Events Parque Natural Obô de São Tomé and Parque Natural Obô do Príncipe created 25 March: the São Toméan legislative election took place April: the XI Constitutional Government of São Tomé and Príncipe began 18 May - Francisco da Silva succeeded Dionísio Tomé Dias as President of the National Assembly 20 June: João Paulo Cassandra becomes President of the Regional Government of Príncipe 30 July: the São Toméan presidential election took place 5 October: José Cassandra becomes President of the Regional Government of Príncipe
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