The Brookings University Residential Historic District is a historic district in Brookings, South Dakota which was listed on the National Register of Historic Places in 1999.

The district included 303 contributing buildings. It is roughly bounded by Harvey Dunn St., Medary Ave., Sixth St., and Main Ave. in Brookings.

It is roughly a four-block by four-and-a-half-block rectangle situated two blocks east of Brookings' Main Street. It includes some of the oldest buildings in the town. With .

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