Melikhov () is a surname. It may refer to:
Aleksandr Melikhov (born 1998), Russian football player Anatoli Melikhov (born 1943), Kazakhstani ice hockey coach Artyom Melikhov, Russian tenor singer Igor Melikhov (born 1944), Russian diplomat Yury Melikhov (1937–2000), Russian cyclist
See also Melikhovo, a writer's house museum in the former country estate of the Russian playwright and writer Anton Chekhov. The estate is about forty miles south of Moscow near Chekhov