4-HO-EPT

4-HO-EPT, also known as 4-hydroxy-N-ethyl-N-propyltryptamine or as eprocin, is a psychedelic drug of the tryptamine family, which is structurally related to psilocin (4-HO-DMT). It was encountered as a novel designer drug in Japan by 2021.

Use and effects 4-HO-EPT was not included nor mentioned in Alexander Shulgin's book TiHKAL (Tryptamines I Have Known and Loved). Subsequently, however, an assumed prodrug of 4-HO-EPT, 4-AcO-EPT, has emerged as a novel designer drug, and has been said based on online anecdotal reports to have a dose of 20 to 30mg orally.

Interactions

Pharmacology Pharmacodynamics + Target Affinity (Ki, nM) 5-HT1A 163 5-HT1B 1,097 5-HT1D 644 5-HT1E 591 5-HT2A 546 (Ki)3.2 ()100% () 5-HT2B 62 (Ki)4.3 ()89% () 5-HT2C 1,272 (Ki)129 ()89% () 5-HT5A 1,576 5-HT6 284 5-HT7 438 α2A 2,073 α2B, α2C >10,000 D2 3,010 D3 985 D4, D5 >10,000 H1 406 H2 >10,000 M4 >10,000 σ1 1,400 σ2 1,773 >10,000 NR2B 5,947 1,257 >10,000 Notes: The smaller the value, the more avidly the drug interacts with the site. Sources:

4-HO-EPT is a potent full agonist of the serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptors. It has one to two orders of magnitude greater potency as a serotonin 5-HT2A and 5-HT2B receptor agonist than as a serotonin 5-HT2C receptor agonist. The drug also shows affinity for other serotonin receptors, such as the serotonin 5-HT1A and 5-HT6 receptors. 4-HO-EPT produces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents.

Pharmacokinetics The metabolism of 4-HO-EPT has been studied.

Chemistry Analogues Analogues of 4-HO-EPT include ethylpropyltryptamine (EPT), 5-MeO-EPT, 5-fluoro-EPT, 4-HO-MPT, 4-HO-PiPT, 4-HO-DET, and 4-HO-DPT, among others.

Society and culture Legal status Canada 4-HO-EPT is not a controlled substance in Canada as of 2025.

United Kingdom 4-HO-EPT is illegal in the United Kingdom as a result of the Psychoactive Substances Act of 2016.

United States 4-HO-EPT may be considered an analogue of psilocin, which is a Schedule I drug under the Controlled Substances Act. As such, the sale for human consumption would be illegal under the Federal Analogue Act.

4-HO-EPT

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