Ōsugi, Osugi, Oosugi or Ohsugi (written: 大杉 lit. "big sugi") is a Japanese surname. Notable people with the surname include:

Isamu Osugi, Japanese mixed martial artist , Japanese baseball player , Japanese singer , Japanese footballer , Japanese actor , Japanese anarchist , Japanese professional wrestler

See also Ōsugi Station, a railway station in Ōtoyo, Nagaoka District, Kōchi Prefecture, Japan