Saffo may refer to:
Saffo (Mayr), 1794 opera by Mayr Saffo (Pacini), 1840 opera by Pacini Saffo in Leucade, by Francesco Morlacchi (1784–1841) Paul Saffo (born 1954), American technology forecaster Saffo the Greek, American organised crime figure, early 20th century Saffo Music, 1977 album by Lara Saint Paul Bill Saffo, Mayor of Wilmington, North Carolina
See also Balcha Safo (1863–1936), Ethiopian general, alternative spelling Sapho (disambiguation) Sappho, Greek poet Sappho (disambiguation)