Sisam is the Ottoman Turkish name for the island of Samos, Greece.
Sisam may also refer to: Ainu word for a Japanese person Sisam hypothesis on royal genealogies Syresham, UK village from which the English name Sisam is derived
People with the surname Sisam Charles Herschel Sisam (1879–1964), an American mathematician Kenneth Sisam (1887-1971), a New Zealand academic and publisher