Rupertus is a surname. Notable people with the surname include:
Glenn Rupertus, Canadian former biathlete Jacob Rupertus (1822/1823–1921), American handgun designer and manufacturer William H. Rupertus (1889–1945), American major general in the United States Marine Corps
See also Rupertus Meldenius, aka Peter Meiderlin and Peter Meuderlinus, (1582 1651), German Lutheran theologian and educator Rupertus Tuitensis (c. 1075/1080 – c. 1129), Belgian benedictine theologian, exegete and writer on liturgical and musical topics was a Gearing-class destroyer of the United States Navy
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