Tatton Sykes or Sir Tatton Sykes may refer to:

People Sir Tatton Sykes, 4th Baronet, (1772–1863), English landowner and stock breeder Sir Tatton Sykes, 5th Baronet, (1826–1913), English landowner, racehorse breeder and eccentric

Other uses Sir Tatton Sykes (horse), a racehorse