De Argüello () is a Spanish surname. Notable people with the surname include:
Fernando de Argüello (1644–1647), Spanish soldier and Governor of New Mexico Francisco José Gómez de Argüello y Wirtz, also known as Kiko Argüello (born 1939), Spanish artist and co-initiator of the Neocatechumenal Way María Soledad Ortega de Argüello (1797–1874), Californio ranchera and socialite
See also Arguello, comune in Italy Argüello