Clendenin is a surname. Notable people with the surname include:
David Clendenin (fl. 1800s–1810s), American investor, soldier, and politician David Ramsay Clendenin (1830–1895), American Union Army officer John J. Clendenin (1813–1876), justice of the Arkansas Supreme Court John L. Clendenin (born 1934), American businessman Michael Clendenin (1934–2017), American journalist