Spittle is an English surname, referring to someone who worked in a . Notable persons with the surname include:
Alison Spittle, Irish comedian and writer Billy Spittle (1893–1979), English professional footballer Denys Spittle (1920–2003), English archaeologist Margaret Spittle (born 1939), British oncologist Max Spittle (1920–2015), Australian rules footballer Rod Spittle, Canadian golfer