Calcagni is a surname of Italian origin. Notable people with the surname include:
Antonio Calcagni (1538–1593), Italian sculptor Filippo Calcagni (born 1980), Italian DJ (also known as DJ Mad Dog) Patrick Calcagni (born 1977), Swiss professional road bicycle racer Ron Calcagni (1957), American former football quarterback Tiberio Calcagni (1532–1565), Italian sculptor