Bortoluzzi is an Italian surname. Notable people with the surname include:
Diego Bortoluzzi (born 1966), Italian footballer and manager Ferruccio Bortoluzzi (1920–2007), Italian painter and sculptor Jérôme Bortoluzzi (born 1982), French hammer thrower Marinella Bortoluzzi (1939–2024), Italian high jumper Roberto Bortoluzzi (1921–2007), Italian sports journalist and radio broadcaster