Duplessis is a French surname. Notable people with the name include:
Georges Duplessis, a French art historian Jerry Duplessis, a composer and record producer José María Imbert Duplessis (1798–1847), a French-born Dominican Republic independence war commandant and national hero Joseph Duplessis, a French painter Lucile Duplessis, a French Revolutionary figure, wife of Camille Desmoulins Marie Duplessis, a French courtesan and mistress Maurice Duplessis (1890-1959), a premier of Québec in the mid twentieth century Rachel Blau DuPlessis (b. 1941), an American poet and editor of George Oppen's Selected Letters Thomas Duplessis (born Thomas-Antoine de Mauduit du Plessis) (1753–1791), a French officer who fought with the Continental Army during the American Revolutionary War