Huene is a surname and given name. Notable people with the name include:
Oswald von Hoyningen-Huene (1885-1963), German diplomat Friedrich von Huene (1875–1969), German paleontologist George Hoyningen-Huene (1900–1968), Russian-born fashion photographer Paul Hoyningen-Huene (born 1946), German philosopher Huenes Marcelo Lemos (born 1981), Brazilian football player