Leo E. Hollister (December 3, 1920 - December 19, 2000) was an American professor emeritus of medicine, psychiatry and pharmacology.

Work on hallucinogens L. E. Hollister's criteria for establishing that a drug is hallucinogenic are as follows:Glennon RA. Classical drugs: an introductory overview. In Lin GC and Glennon RA (eds). Hallucinogens: an update . National Institute on Drug Abuse: Rockville, MD, 1994. in proportion to other effects, changes in thought, perception, and mood should predominate; intellectual or memory impairment should be minimal; stupor, narcosis, or excessive stimulation should not be an integral effect; autonomic nervous system side effects should be minimal; and addictive craving should be absent.

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