Panagopoulos () is a Greek surname. Notable people with the surname include:
Andreas Panagopoulos (1883–1952), Greek politician Costas Panagopoulos, American political scientist Leonidas Panagopoulos (born 1987), Greek footballer Nicolas Panagopoulos (born 1954), Greek composer Panayotis Panagopoulos (1916–unknown), Greek chess player Pericles Panagopoulos (1935–2019), Greek shipping magnate Theo Ryuki Panagopoulos (born 1995), Japanese footballer