Ōsaki, Osaki, Oosaki or Ohsaki (written: ) is a Japanese surname. Notable people with the surname include:
, Japanese footballer , Japanese-born American soccer player Makoto Osaki, developer and supervisor at Sega AM2, involved with the Shenmue, Out Run, and Virtua Fighter games, among others , Japanese long-distance runner , Japanese swimmer , Japanese baseball player Shotaro (rapper), full name , Japanese rapper, singer and dancer
Fictional characters , a character in the manga series Nana , a character in the manga series Akane-banashi