Stephen II of Antioch (died in 479) was a Patriarch of AntiochIstván Perczel, Réka Forrai, György Geréby (2005), The Eucharist in Theology and Philosophy - Issues of Doctrinal History in East and West from the Patristic Age to the Reformation, Leuven University Press. from 477 until his death.

Biography It is unknown when Stephen was born. He became a Patriarch in 477, and he was a successor of John II of Antioch,A. Fortescue, The lesser eastern churches, p. 192. who held the see only three months and was exiled. Stephen was killed in 479Aloys Grillmeier, Pauline Allen (1986), Christ in Christian Tradition - From the Council of Chalcedon (451) to Pope Gregory the Great (590-604), Westminster John Knox Press.David A. Michelson (2014), The Practical Christology of Philoxenos of Mabbug, p. 10. and was succeeded by Calendion of Antioch.

He is venerated as a martyr saint on 25 April.

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