The 2018 Major League Baseball draft began on June 4, 2018. The draft assigned amateur baseball players to MLB teams. The draft order was determined based on the reverse order of the 2017 MLB season final standings. In addition, compensation picks were distributed for players who did not sign from the 2017 MLB draft and for teams who lost qualifying free agents. The first 43 picks, including the first round and compensatory picks, were broadcast by MLB Network on June 4. The remainder of the draft was streamed on MLB.com on June 5 and 6.

With a tie for the worst record in the 2017 MLB season at 64–98, the Detroit Tigers received the first overall pick ahead of the San Francisco Giants via a tiebreaker. The Detroit Tigers selected Casey Mize with the first overall pick in the draft. There were a total of 40 rounds in the draft, with 1,214 players selected.

On September 9, 2019, the Chicago Cubs promoted Nico Hoerner to the big leagues, making him the first player to reach MLB in this draft.

First round selections +Key All-Star*Player did not sign Pick Player Team Position School1Detroit TigersPitcherAuburn2San Francisco GiantsCatcherGeorgia Tech3Philadelphia PhilliesThird basemanWichita State4Chicago White SoxShortstopOregon State5Cincinnati RedsThird basemanFlorida6New York MetsOutfielderWaukesha West High School (WI)7San Diego PadresPitcherLoretto High School (TN)8*Atlanta BravesPitcherEau Gallie High School (FL)9Oakland AthleticsOutfielderOklahoma10Pittsburgh PiratesOutfielderSouth Alabama11 Baltimore OriolesPitcherCentral Heights High School (TX)12Toronto Blue JaysShortstopMagnolia High School (TX)13Miami MarlinsOutfielderPlant High School (FL)14Seattle MarinersPitcherStetson15Texas RangersPitcherOrange Lutheran High School (CA)16Tampa Bay RaysPitcherMountain Ridge High School (AZ)17Los Angeles AngelsOutfielderGreen Hope High School (NC)18Kansas City RoyalsPitcherFlorida19St. Louis CardinalsThird basemanSandra Day O'Connor High School (AZ)20Minnesota TwinsOutfielderOregon State21Milwaukee BrewersShortstopSantiago High School (CA)22Colorado RockiesPitcherOle Miss23New York YankeesCatcherCartersville High School (GA)24Chicago CubsShortstopStanford25*Arizona DiamondbacksShortstopBeckman High School (CA)26Boston Red SoxInfielderAmerican Heritage School (FL)27Washington NationalsPitcherMerritt Island High School (FL)28Houston AstrosOutfielderClemson29Cleveland IndiansCatcherSt. Joan of Arc Catholic Secondary School (ON)30*Los Angeles DodgersPitcherBrandon High School (MS)

Compensatory round Pick Player Team Position School31Tampa Bay RaysPitcherSouth Florida32Tampa Bay RaysOutfielderRoncalli High School (IN)33Kansas City RoyalsPitcherFlorida34Kansas City RoyalsPitcherVirginia35Cleveland IndiansPitcherForsyth Central High School (GA)

Competitive balance round A Pick Player Team Position School36*Pittsburgh PiratesPitcher Fivay High School (FL)37Baltimore OriolesShortstopOregon State38San Diego PadresShortstopNorth Broward Preparatory School (FL)39Arizona DiamondbacksOutfielderVirginia40Kansas City RoyalsPitcherStanford41Cleveland IndiansPitcherBeacon High School (NY)42Colorado RockiesFirst basemanBedford High School (NH)43St. Louis CardinalsPitcherWake Forest

Other notable selections