Alkire is a surname. Notable people with the surname include:
Darr H. Alkire (1903–1977), United States Air Force general Elbern Alkire (1907–1981), American guitarist Jason Alkire, American fashion designer Sabina Alkire (* 1969), German academic
See also Haus Alkire, an American fashion label Alkire House, a historic house in Westerville, Ohio, United States