Motherfucker is an English-language vulgarism.

Motherfucker may also refer to:

Up Against the Wall Motherfucker, otherwise known simply as The Motherfuckers, a 1960s anarchist group "Motherfucker" (Faith No More song), 2014 "Motherfucker" (Primitive Radio Gods song), 1996 "Motherfucker" (Robbie Williams song), 2016 "Motherfucker" (Entourage), a 2011 TV episode The Motherfucker, a character from the Kick-Ass 2 comic, 2013