Missoni is an Italian surname. Notable people with the surname include:
Eduardo Missoni (born 1954), Italian medical doctor Margherita Missoni (born 1983), Italian fashion designer, model and actress Ottavio Missoni (1921–2013), Italian founder of the fashion label Missoni Roberta Missoni (born Floriana Panella in 1980), Italian pornographic actress Rosita Missoni (1931–2025), Italian knitwear designer, wife of Ottavio Vittorio Missoni (1954–2013), Italian CEO of Missoni, the fashion house founded by Ottavio Missoni
See also Missoni, high-end Italian fashion house