Brignone is an Italian surname. Notable people with the surname include:
Federica Brignone (born 1990), Italian World Cup alpine ski racer Guido Brignone (1886–1959), Italian film director and actor Lilla Brignone (1913–1984), Italian film and theater actress Mercedes Brignone (1885–1967), Spanish-born Italian stage, film and television actress Nicolas Brignone (born 1989), French para-sport athlete