Giant Killers or Giant Killer may refer to:

Entertainment Giant Killers (EP), a 2017 EP by BiSH Giant Killers (video game), a 2001 video game "Giant Killer" (story), a 1945 short story by A. Bertram Chandler The Giant Killer, the British title of the 2013 American film Jack the Giant Killer Giantkiller, an American comic book series

Sports Giant killers (sports), underdogs who defeat favorites (or top dogs) 1967 Oregon State Beavers football team, an American college football team nicknamed "Giant Killers"

Other uses Giant Killer (call sign), an American military aviation call sign

See also Giant-killing (disambiguation)