Mellini is an Italian surname. Notable people with the surname include:
Clarissimo Falconieri Mellini (1794–1859), Italian Catholic cardinal and Camerlengo of the Sacred College of Cardinals Giovanni Battista Mellini (1405–1478), Italian Roman Catholic bishop and cardinal Giovanni Garzia Mellini (1562–1629), Italian Roman Catholic prelate, Camerlengo of the Sacred College of Cardinals Marie Azpiroz Mellini (1889–?), Spanish violinist Mauro Mellini (1927–2020), Italian lawyer and politician
See also Mellini Chapel (Santa Maria del Popolo), chapel in the Church of Santa Maria del Popolo in Rome Ponte Mellini, small village (curazia) of San Marino