South Cairo is a hamlet (and census-designated place). It has 590 people, as of the 2020 census.U.S. Census Bureau, 2020 census results. https://www.census.gov/search-results.html?searchType=web&cssp=SERP&q=South%20Cairo%20CDP,%20New%20York It is situated in Greene County, New York, United States. The community is located along Catskill Creek and New York State Route 23, northwest of Catskill.

South Cairo has a post office with ZIP code 12482.

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