Gisler is a surname. Notable people with the surname include:
Felix Gisler, Swiss para-alpine skier Joel Gisler (born 1994), Swiss freestyle skier Lisa Gisler (born 1994), Swiss curler Marcel Gisler (born 1960), Swiss film director and screenwriter Mike Gisler (born 1969), American football player Rolf Gisler (born 1953), Swiss sprinter