Giuffrida is an Italian surname. Notable people with the surname include:
Alfio Giuffrida (born 1953), Italian sculptor Giuseppe De Felice Giuffrida (1859–1920), Italian socialist politician and journalist Louis O. Giuffrida (1920–2012), first director of the Federal Emergency Management Agency from 1981 to 1985 Odette Giuffrida (born 1994), Italian judoka
See also Giuffrida metro station, located in Catania in Sicily, southern Italy