Sypher is a surname. Notable people with the surname include:
J. Hale Sypher (1837–1905), American attorney and politician Lucy Johnston Sypher (1907–1990), American children's writer Marjorie Elliott Sypher (1925–2015), Canadian-born Costa Rican musician Wylie Sypher (1905–1987), American non-fiction writer and academic
See also
SypherPK (born 1996), American streamer and YouTuber