Adenine nucleotide translocase lysine N-methyltransferase is an enzyme that in humans is encoded by the ANTKMT gene (previously FAM173A). This enzyme is involved in regulating cellular respiration in the mitochondria. In particular it functions to (tri)methylate the transporters SLC25A5 (ANT2) and SLC25A6 (ANT3), and probably SLC25A4 (ANT1) as well.
Enzyme activity This enzyme catalyzes the following reaction:
L-lysyl-[protein] + 3 S-adenosyl-L-methionine → N6,N6,N6-trimethyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H+
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