Plascencia is a surname. Notable people with the surname include:
Benjamín Castillo Plascencia (1945–2026), Mexican Roman Catholic prelate Francisco Javier Plascencia Alonso (born 1956), Mexican politician Gabriel Plascencia (born 2001), American football player Javier Plascencia (born 1967), Mexican chef Salvador Plascencia (born 1976), American writer
See also Alfredo Placencia (1875–1930), Mexican priest and poet Placencia, a town in Belize