Peixotto is a surname. Notable people with the surname include:
Becca Peixotto, American archaeologist Benjamin F. Peixotto (1834–1890), American lawyer and diplomat Bridget Peixotto (1877–1972), American educator, union leader Daniel Levy Maduro Peixotto (1800–1843), Dutch-American physician Edgar D. Peixotto (1867–1925), American lawyer Ernest Peixotto (1869–1940), American artist, illustrator, and writer Grace Peixotto (1817–1880), American brothel owner Jessica Blanche Peixotto (1864–1941), Jewish-American educator and writer Judith Salzedo Peixotto (1823–1881), Jewish-American teacher and principal Raphael Peixotto (1837–1905), Jewish-American merchant