Day 1 (August 29) Top American Mardy Fish opened proceedings cruising past German Tobias Kamke 6–2, 6–2, 6–1. While, another American Ryan Harrison fell to 27th seed Marin Čilić 6–2, 7–5, 7–6(8–6), after wasting leads in the second and third set. No. 13 seed Richard Gasquet then played the inaugural match at the newest show court, Court 17, defeating Sergiy Stakhovsky in straight sets 6–4, 6–4, 6–0. Five-time champion and 3rd seed Roger Federer defeated Santiago Giraldo 6–4, 6–3, 6–2. Other seeds who cruised through were Gaël Monfils, Tomáš Berdych, Alexandr Dolgopolov, Radek Štěpánek and Janko Tipsarević. While 15th seed Viktor Troicki and 29th seed Michaël Llodra, were both pushed to a final set with Llodra prevailing over Victor Hănescu, while Troicki was the first upset of the tournament losing to Alejandro Falla.
On the women's side former champion Maria Sharapova was pushed by Britain's Heather Watson in three sets 3–6, 7–5, 6–3. While, the American woman had mixed results, out of 8 on court 4 of them being led by 2-time champion Venus Williams, Madison Keys, Irina Falconi, and Christina McHale. Most of the top seeds also advanced to the second round, led by last year's finalist and 2nd seed Vera Zvonareva, the Russian was joined by Marion Bartoli, Samantha Stosur, Agnieszka Radwańska, Peng Shuai and Dominika Cibulková. The major upset of the opening day saw Wimbledon Champion Petra Kvitová as she fell to Alexandra Dulgheru in straight sets 7–6(7–3), 6–3, hitting 52 unforced errors. This also marks the first time in the Open Era that a reigning Wimbledon Champion has lost in the first round of the US Open. Schedule of Play Seeds out: Men's Singles: Viktor Troicki Women's Singles: Petra Kvitová
Matches on main courtsEventWinnerLoserScoreMatches on Arthur Ashe StadiumMen's Singles 1st Round Mardy Fish Tobias Kamke 6–2, 6–2, 6–1Women's Singles 1st Round Maria Sharapova Heather Watson 3–6, 7–5, 6–32011 US Open Opening Night CeremonyWomen's Singles 1st Round Venus Williams Vesna Dolonts6–4, 6–3Men's Singles 1st Round Roger Federer Santiago Giraldo6–4, 6–3, 6–2Matches on Louis Armstrong StadiumMen's Singles 1st Round Marin Čilić Ryan Harrison [WC] 6–2, 7–5, 7–6(8–6)Women's Singles 1st Round Alexandra Dulgheru Petra Kvitová 7–6(7–3), 6–3Women's Singles 1st Round Vera Zvonareva Stéphanie Foretz Gacon [Q] 6–3, 6–0Women's Singles 1st Round Marion Bartoli Alexandra Panova [Q] 7–5, 6–3Men's Singles 1st Round Gaël Monfils Grigor Dimitrov7–6(7–4), 6–3, 6–4Matches on the GrandstandMen's Singles 1st Round Tomáš Berdych Romain Jouan [Q] 6–2, 7–6(7–4), 6–1Women's Singles 1st Round Madison Keys [WC] Jill Craybas [WC] 6–2, 6–4Men's Singles 1st Round Alejandro Falla Victor Troicki 3–6, 6–3, 4–6, 7–5, 7–5Women's Singles 1st Round Polona Hercog Bethanie Mattek-Sands6–1, 6–3Colored background indicates a night match
Day 2 (August 30) Schedule of Play Seeds out: Men's Singles: Mikhail Youzhny , Ivan Dodig Women's Singles: Li Na , Daniela Hantuchová , María José Martínez Sánchez Matches on main courtsEventWinnerLoserScoreMatches on Arthur Ashe StadiumWomen's Singles 1st Round Victoria Azarenka Johanna Larsson6–1, 6–3Women's Singles 1st Round Caroline Wozniacki Nuria Llagostera Vives6–3, 6–1Men's Singles 1st Round Novak Djokovic Conor Niland [Q]6–0, 5–1, retiredWomen's Singles 1st Round Ana Ivanovic Ksenia Pervak6–4, 6–2Men's Singles 1st Round Rafael Nadal Andrey Golubev6–3, 7–6(7–1), 7–5Women's Singles 1st Round Serena Williams Bojana Jovanovski6–1, 6–1Matches on Louis Armstrong StadiumMen's Singles 1st Round David Ferrer Igor Andreev2–6, 6–3, 6–0, 6–4Women's Singles 1st Round Francesca Schiavone Galina Voskoboeva [Q]6–3, 1–6, 6–4Women's Singles 1st Round Simona Halep Li Na 6–2, 7–5Men's Singles 1st Round James Blake Jesse Huta Galung [Q] 6–4, 6–2, 4–6, 6–4Matches on the GrandstandMen's Singles 1st Round Jo-Wilfried Tsonga Lu Yen-hsun6–4, 6–4, 6–4Women's Singles 1st Round Jelena Janković Alison Riske [WC]6–2, 6–0Men's Singles 1st Round Fernando Verdasco Jarkko Nieminen3–6, 6–4, 6–1, 6–4Colored background indicates a night match
Day 3 (August 31) Schedule of Play Seeds out: Men's Singles: Nicolás Almagro Women's Singles: Marion Bartoli , Agnieszka Radwańska , Dominika Cibulková , Yanina Wickmayer Men's Doubles: Bob Bryan / Mike Bryan , František Čermák / Filip Polášek , Scott Lipsky / Rajeev Ram Women's Doubles: Chan Yung-jan / Anastasia Rodionova , Chuang Chia-jung / Olga Govortsova Matches on main courtsEventWinnerLoserScoreMatches on Arthur Ashe StadiumWomen's Singles 2nd Round Vera Zvonareva Kateryna Bondarenko 7–5, 3–6, 6–3Men's Singles 1st Round Andy Murray Somdev Devvarman 7–6(7–5), 6–2, 6–3Women's Singles 2nd Round Sabine Lisicki Venus WilliamswalkoverWomen's Singles 2nd Round Irina Falconi Dominika Cibulková 2–6, 6–3, 7–5Men's Singles 1st Round Andy Roddick Michael Russell 6–2, 6–4, 4–6, 7–5Women's Singles 2nd Round Maria Sharapova Anastasiya Yakimova 6–1, 6–1Matches on Louis Armstrong StadiumWomen's Singles 2nd Round Lucie Šafářová Madison Keys [WC] 3–6, 7–5, 6–4Men's Singles 1st Round Juan Martín del Potro Filippo Volandri 6–3, 6–1, 6–1Women's Singles 2nd Round Samantha Stosur Coco Vandeweghe 6–3, 6–4Men's Singles 1st Round John Isner Marcos Baghdatis 7–6(7–2), 7–6(13–11), 2–6, 6–4Matches on the GrandstandMen's Singles 1st Round Rogério Dutra da Silva [LL] Louk Sorensen [Q] 6–0, 3–6, 6–4, 1–0, retiredWomen's Singles 2nd Round Christina McHale Marion Bartoli 7–6(7–2), 6–2Men's Singles 1st Round Robby Ginepri [WC] João Souza [Q] 6–3, 6–4, 6–7(5–7), 6–1Women's Singles 2nd Round Angelique Kerber Agnieszka Radwańska 6–3, 4–6, 6–3Colored background indicates a night match
Day 4 (September 1) Schedule of Play Seeds out: Men's Singles: Gaël Monfils , Richard Gasquet , Radek Štěpánek , Michaël Llodra Women's Singles: Shahar Pe'er , Jarmila Gajdošová , Kaia Kanepi Men's Doubles: Christopher Kas / Alexander Peya Women's Doubles: Peng Shuai / Zheng Jie , Natalie Grandin / Vladimíra Uhlířová Mixed Doubles: Yaroslava Shvedova / Max Mirnyi , Sania Mirza / Mahesh Bhupathi Matches on main courtsEventWinnerLoserScoreMatches on Arthur Ashe StadiumWomen's Singles 2nd Round Francesca Schiavone Mirjana Lučić 6–1, 6–1Men's Singles 2nd Round Roger Federer Dudi Sela 6–3, 6–2, 6–2Women's Singles 2nd Round Serena Williams Michaëlla Krajicek [Q] 6–0, 6–1Women's Singles 2nd Round Caroline Wozniacki Arantxa Rus 6–2, 6–0Men's Singles 2nd Round Novak Djokovic Carlos Berlocq 6–0, 6–0, 6–2Matches on Louis Armstrong StadiumWomen's Singles 2nd Round Jelena Janković Jelena Dokić 6–3, 6–4Men's Singles 2nd Round Juan Carlos Ferrero Gaël Monfils 7–6(7–5), 5–7, 6–7(5–7), 6–4, 6–4Men's Singles 2nd Round Mardy Fish Malek Jaziri [Q] 6–2, 6–2, 6–4Women's Singles 2nd Round Victoria Azarenka Gisela Dulko 6–4, 6–3Matches on the GrandstandMen's Singles 2nd Round Tomáš Berdych Fabio Fognini 7–5, 6–0, 6–0Women's Singles 2nd Round Andrea Petkovic Jie Zheng 3–6, 6–3, 6–3Men's Singles 2nd Round Jo-Wilfried Tsonga Sergei Bubka [Q] 6–3, 7–5, 6–2Women's Singles 2nd Round Sloane Stephens [WC] Shahar Pe'er 6–1, 7–6(7–4)Colored background indicates a night match
Day 5 (September 2) Schedule of Play Seeds out: Men's Singles: Stanislas Wawrinka , Jürgen Melzer , Ivan Ljubičić Women's Singles: Maria Sharapova , Julia Görges , Nadia Petrova , Lucie Šafářová , Anabel Medina Garrigues Men's Doubles: Max Mirnyi / Daniel Nestor , Marcelo Melo / Bruno Soares Women's Doubles: Nuria Llagostera Vives / Arantxa Parra Santonja Mixed Doubles: Vania King / Rohan Bopanna Matches on main courtsEventWinnerLoserScoreMatches on Arthur Ashe StadiumWomen's Singles 3rd Round Vera Zvonareva Anabel Medina Garrigues 6–4, 7–5Women's Singles 3rd Round Flavia Pennetta Maria Sharapova 6–3, 3–6, 6–4Men's Singles 2nd Round Rafael Nadal Nicolas Mahut 6–2, 6–2, retiredWomen's Singles 3rd Round Maria Kirilenko Christina McHale 6–2, 6–3Men's Singles 2nd Round Andy Roddick Jack Sock 6–3, 6–3, 6–4Matches on Louis Armstrong StadiumWomen's Singles 3rd Round Monica Niculescu Lucie Šafářová 6–0, 6–1Men's Singles 2nd Round John Isner Robby Ginepri [WC] 6–4, 6–3, 6–4Men's Singles 2nd Round Andy Murray Robin Haase 6–7(5–7), 2–6, 6–2, 6–0, 6–4Women's Singles 3rd Round Samantha Stosur Nadia Petrova 7–6(7–5), 6–7(5–7), 7–5Matches on the GrandstandMen's Singles 2nd Round Juan Martín del Potro Diego Junqueira 6–2, 6–1, 7–5Women's Singles 3rd Round Peng Shuai Julia Görges 6–4, 7–6(7–1)Women's Singles 3rd Round Sabine Lisicki Irina Falconi 6–0, 6–1Men's Singles 2nd Round David Ferrer James Blake 6–4, 6–3, 6–4Colored background indicates a night match
Day 6 (September 3) Schedule of Play Seeds out: Men's Singles: Tomáš Berdych , Fernando Verdasco , Marin Čilić , Marcel Granollers Women's Singles: Victoria Azarenka , Jelena Janković , Roberta Vinci Men's Doubles: Eric Butorac / Jean-Julien Rojer , Juan Ignacio Chela / Eduardo Schwank Mixed Doubles: Liezel Huber / Bob Bryan , Katarina Srebotnik / Daniel Nestor Matches on main courtsEventWinnerLoserScoreMatches on Arthur Ashe StadiumWomen's Singles 3rd Round Caroline Wozniacki Vania King6–2, 6–4Men's Singles 3rd Round Roger Federer Marin Čilić 6–3, 4–6, 6–4, 6–2Women's Singles 3rd Round Serena Williams Victoria Azarenka 6–1, 7–6(7–5)Women's Singles 3rd Round Ana Ivanovic Sloane Stephens [WC] 6–3, 6–4Men's Singles 3rd Round Novak Djokovic Nikolay Davydenko 6–3, 6–4, 6–2Matches on Louis Armstrong StadiumMen's Singles 3rd Round Janko Tipsarević Tomáš Berdych 6–4, 5–0, retiredWomen's Singles 3rd Round Anastasia Pavlyuchenkova Jelena Janković 6–4, 6–4Men's Singles 3rd Round Mardy Fish Kevin Anderson6–4, 7–6(7–4), 7–6(7–3)Women's Singles 3rd Round Svetlana Kuznetsova Akgul Amanmuradova6–4, 6–2Matches on the GrandstandWomen's Singles 3rd Round Francesca Schiavone Chanelle Scheepers5–7, 7–6(7–5), 6–3Women's Singles 3rd Round Andrea Petkovic Roberta Vinci 6–4, 6–0Men's Singles 3rd Round Juan Mónaco Tommy Haas [PR]6–7(3–7), 6–3, 6–2, 6–3Men's Singles 3rd Round Jo-Wilfried Tsonga Fernando Verdasco 6–3, 7–5, 6–4Colored background indicates a night match
Day 7 (September 4) Schedule of Play Seeds out: Men's Singles: Juan Martín del Potro , Juan Ignacio Chela , Feliciano López , Florian Mayer Women's Singles: Peng Shuai , Sabine Lisicki , Maria Kirilenko Men's Doubles: Marcel Granollers / Marc López (withdrew), Mark Knowles / Xavier Malisse Women's Doubles: Sania Mirza / Elena Vesnina , Jarmila Gajdošová / Bethanie Mattek-Sands Matches on main courtsEventWinnerLoserScoreMatches on Arthur Ashe StadiumMen's Singles 3rd Round Rafael Nadal David Nalbandian7–6(7–5), 6–1, 7–5Men's Singles 3rd Round Andy Roddick Julien Benneteau [WC]6–1, 6–4, 7–6(7–5) Men's Singles 3rd Round Andy Murray Feliciano López 6–1, 6–4, 6–2Women's Singles 4th Round Vera Zvonareva Sabine Lisicki 6–2, 6–3Matches on Louis Armstrong StadiumWomen's Singles 4th Round Flavia Pennetta Peng Shuai 6–4, 7–6(8–6)Men's Singles 3rd Round Gilles Simon Juan Martín del Potro 4–6, 7–6(7–5), 6–2, 7–6(7–3)Men's Singles 3rd Round John Isner Alex Bogomolov, Jr. 7–6(11–9), 6–4, 6–4Matches on the GrandstandMen's Singles 3rd Round Gilles Müller Igor Kunitsyn6–1, 6–4, 6–4Men's Singles 3rd Round Donald Young [WC] Juan Ignacio Chela 7–5, 6–4, 6–3Women's Doubles 3rd Round Liezel Huber Lisa Raymond Jarmila Gajdošová Bethanie Mattek-Sands 6–2, 7–6(7–5)Women's Singles 4th Round Samantha Stosur Maria Kirilenko 6–2, 6–7(15–17), 6–3Colored background indicates a night match
Day 8 (September 5) Schedule of Play Seeds out: Men's Singles: Mardy Fish , Alexandr Dolgopolov Women's Singles: Francesca Schiavone , Svetlana Kuznetsova , Ana Ivanovic Men's Doubles: Michaël Llodra / Nenad Zimonjić Women's Doubles: Gisela Dulko / Flavia Pennetta , María José Martínez Sánchez / Anabel Medina Garrigues