Guêpe or La Guêpe (French "The Wasp") may refer to:
Books and publications La Guêpe, a Canadian humour journal published 1857–1861 La Guêpe, a 1934 novel by Albert Touchard La Guêpe, a 1943 poem by Francis Ponge
Film and TV La Guêpe (film), a 1986 Canadian film by Gilles Carle La Guêpe, a 1965 French TV film by François Leterrier
Transportation La Guêpe (aircraft), French ultralight aircraft La Guêpe (ship), privateer captured by the Royal Navy in 1800, then HMS Wasp
Other uses Arthur Guepe (1915–2001), American football player and head coach at the University of Virginia Guêpe-class submarine, a class of French attack submarines