Cuello is a Spanish surname. Notable people with the surname include:
Claudio Cuello (born 1958), Argentine volleyball player and coach Denver Cuello (born 1986), Filipino boxer Emil Cuello (born 1997), Argentine and American footballer Federico Cuello Camilo (born 1966), Dominican Republic diplomat Luciano Leonel Cuello (born 1984), Argentine boxer Miguel Ángel Cuello (1946–1999), Argentine boxer Román Cuello (born 1977), Uruguayan footballer Tomás Cuello (born 2000), Argentine footballer