Sethupathis () were 17th century rulers of the Ramnad and Sivaganga regions in southern India.
Sethupathi may also refer to:
Sethupathi (surname) Sethupathi (film), a 2016 Indian Tamil-language film Sethupathi Higher Secondary School in Madurai, India Sethupathi, a fictional character in the Indian Baahubali franchise
See also Sethu (disambiguation) Pati (disambiguation)