Sposito is an Italian surname. Notable people with the surname include:
Carlo Sposito (1924–1984), Italian actor Raffaele Sposito (1922–1981), Italian playwright better known as Faele Rafael Spósito Balzarini (1952–2009), Uruguayan anarchist Santino Sposito (born 2002), Argentine beach handball player
See also Esposito Sposato